IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.

doi:10.1046/j.1365-2141.2000.01971.x

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Article

IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.

British journal of haematology - 1 Apr 2000

Garand R, Sahota S S, Avet-Loiseau H, Talmant P, Robillard N, Moreau A, Gaillard F, Stevenson F K, Bataille R

Abstract excerpt

We investigated 16 patients with elevated serum monoclonal IgG and a leukaemic B-cell lymphocytic disorder different from multiple myeloma. Their clinical history was that of a non-aggressive disease with dominant splenomegaly and long survival. Whereas abnormal blood and bone marrow cells were predominantly small lymphocytes with a few lymphoplasmacytoid cells, histopathological features included a...

Topics

Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 13
Cytogenetic Analysis
Female
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Immunoglobulin

Humans

Immunoglobulin Class Switching

Immunoglobulin G

Immunophenotyping

In Situ Hybridization, Fluorescence

Leukemia, Lymphocytic, Chronic, B-Cell

Leukemia, Plasma Cell

Source

Open in PubMed

Identifiers

PMID: 10848784
DOI: 10.1046/j.1365-2141.2000.01971.x

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