Article
IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.
British journal of haematology - 1 Apr 2000
Garand R, Sahota S S, Avet-Loiseau H, Talmant P, Robillard N, Moreau A, Gaillard F, Stevenson F K, Bataille R
Abstract excerpt
We investigated 16 patients with elevated serum monoclonal IgG and a leukaemic B-cell lymphocytic disorder different from multiple myeloma. Their clinical history was that of a non-aggressive disease with dominant splenomegaly and long survival. Whereas abnormal blood and bone marrow cells were predominantly small lymphocytes with a few lymphoplasmacytoid cells, histopathological features included a...
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