Article
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage.
Nature - 29 Aug 1996
Tanaka N, Ishihara M, Lamphier M S, Nozawa H, Matsuyama T, Mak T W, Aizawa S, Tokino T, Oren M, Taniguchi T
Abstract excerpt
Normally growing cells promptly cease DNA synthesis when exposed to genotoxic stresses, such as radiation, and this cell-cycle arrest prevents the accumulation of mutations. The transcription factor interferon regulatory factor (IRF)-1 is essential for the regulation of the interferon system, inh...
Topics
- Animals
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- DNA Damage
- DNA-Binding Proteins
- Gamma Rays
- Gene Expression Regulation
- Interferon Regulatory Factor-1
- Mice
- Mutation
- Phosphoproteins
- Promoter Regions, Genetic
- RNA, Messenger
- Transcription Factors
- Tumor Suppressor Protein p53