Article
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage.
Nature - 29 Aug 1996
Tanaka N, Ishihara M, Lamphier M S, Nozawa H, Matsuyama T, Mak T W, Aizawa S, Tokino T, Oren M, Taniguchi T
Abstract excerpt
Normally growing cells promptly cease DNA synthesis when exposed to genotoxic stresses, such as radiation, and this cell-cycle arrest prevents the accumulation of mutations. The transcription factor interferon regulatory factor (IRF)-1 is essential for the regulation of the interferon system, inhibits cell growth, and manifests tumour-suppressor activities. Here we show that mouse embryonic fibroblasts (EFs)...
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