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Article

Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 1998

Prost S, Bellamy C O, Cunningham D S, Harrison D J

Abstract excerpt

The tumor suppressor proteins IRF-1 and p53 are involved in response pathways after DNA damage. In different cell types, IRF-1 and p53 can cooperate to produce cell cycle arrest (embryo fibroblasts) or can independently trigger apoptosis (lymphoid cells). p53 may also regulate DNA repair, but there is no information on IRF-1 and repair. The cell lineage dependency of these effects precludes extrapolation of...

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Identifiers

PMID: 9472983
DOI: 10.1096/fasebj.12.2.181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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