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Article

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes

1 Jan 1993

Abstract excerpt

Interferon regulatory factor 1 (IRF-1) is a DNA-binding factor which recognizes regulatory elements in the promoters of interferon (IFN)-beta and some IFN-inducible genes. We observed that expression of transfected murine IRF-1 in different mammalian cell lines leads to down-regulation or stop of proliferation depending on the extent of expression. Expression of fusion proteins composed of IRF-1 and the hormone...

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PMID: 8332497
DOI: 10.1093/nar/21.12.2881

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Source receipt: pubmed, retrieved 7 Sept 2026.

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