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Article

Molecular pathways: harnessing E2F1 regulation for prosenescence therapy in p53-defective cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2014

Laine Anni, Westermarck Jukka

Abstract excerpt

Induction of terminal proliferation arrest, senescence, is important for in vivo tumor-suppressive function of p53. Moreover, p53-mutant cells are highly resistant to senescence induction by either oncogenic signaling during cellular transformation or in response to different therapies. Senescence resistance in p53-mutant cells has been attributed mostly to inhibition of the checkpoint function of p53 in response...

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Identifiers

PMID: 24788101
DOI: 10.1158/1078-0432.CCR-13-1942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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