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Article

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.

Molecular and cellular biology - 1 Jan 2003

Itahana Koji, Zou Ying, Itahana Yoko, Martinez Jose-Luis, Beausejour Christian, Jacobs Jacqueline J L, Van Lohuizen Maarten, Band Vimla, Campisi Judith, Dimri Goberdhan P

Abstract excerpt

The polycomb protein Bmi-1 represses the INK4a locus, which encodes the tumor suppressors p16 and p14(ARF). Here we report that Bmi-1 is downregulated when WI-38 human fibroblasts undergo replicative senescence, but not quiescence, and extends replicative life span when overexpressed. Life span extension by Bmi-1 required the pRb, but not p53, tumor suppressor protein. Deletion analysis showed that the RING...

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Identifiers

PMID: 12482990
DOI: 10.1128/MCB.23.1.389-401.2003
PMCID: PMC140680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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