Article

Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells

2024-11-11

Abstract excerpt

<h4>ABSTRACT</h4> The tumor suppressors p53 and ARF collaborate to prevent unwarranted cell proliferation and as such are two of the most frequently mutated genes in human cancer. Concomitant loss of functional p53 and ARF leads to massive gains in cell proliferation and transformation and is often observed in some of the most aggressive human cancer subtypes. These phenotypic gains are preceded by increased type...

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Literature Corpus work: 9f6c2411-f39b-50ec-92dc-b65d67270a4c
DOI: 10.1101/2024.11.11.623046

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