Article
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.
Cell - 17 Jun 1994
Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier M S, Aizawa S, Mak T W, Taniguchi T
Abstract excerpt
The transcriptional activator interferon regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the interferon (IFN) system and of cell growth. Here we report that embryonic fibroblasts (EFs) from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice) can be trans...
Topics
- Animals
- Antineoplastic Agents
- Apoptosis
- Base Sequence
- Cell Line
- Cell Survival
- Cell Transformation, Neoplastic
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Interferon Regulatory Factor-1
- Mice
- Mice, Inbred BALB C
- Mice, Knockout