Transcriptional role of p53 in interferon-mediated antiviral immunity

doi:10.1084/jem.20080383

Article

Transcriptional role of p53 in interferon-mediated antiviral immunity

28 Jul 2008

Abstract excerpt

Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda, and T. Taniguchi. 2003. Nature. 424:516-523) have shown that p53 is also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN)...

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