Article
Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample.
Lancet (London, England) - 25 Nov 1995
Henderson A S, Easteal S, Jorm A F, Mackinnon A J, Korten A E, Christensen H, Croft L, Jacomb P A
Abstract excerpt
From clinically based series it has been proposed that, in homozygotes for the apolipoprotein E epsilon 4 (apoE epsilon 4) allele, Alzheimer's disease is almost inevitable by the age of 80. A population sample of persons aged 70 years and over was interviewed in 1990-91 to ascertain the presence...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Cognition Disorders
- Cohort Studies
- Dementia
- Female
- Genotype
- Homozygote
- Humans
- Logistic Models
- Male
- Odds Ratio
- Risk Factors