Article
Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample.
Lancet (London, England) - 25 Nov 1995
Henderson A S, Easteal S, Jorm A F, Mackinnon A J, Korten A E, Christensen H, Croft L, Jacomb P A
Abstract excerpt
From clinically based series it has been proposed that, in homozygotes for the apolipoprotein E epsilon 4 (apoE epsilon 4) allele, Alzheimer's disease is almost inevitable by the age of 80. A population sample of persons aged 70 years and over was interviewed in 1990-91 to ascertain the presence of dementia or cognitive impairment. The sample was reinterviewed in 1994, when the apoE genotype was also determined....
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