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Article

β-catenin and transforming growth factor β have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction

11 May 2009

Abstract excerpt

BACKGROUND: beta-catenin and transforming growth factor beta signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth factor beta is partially mediated by beta-catenin. Other cellular processes, such as cell motility and the induction of extracellular matrix contraction,...

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Share to Connective Tissue Growth Factor Research
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PMID: 19432963
DOI: 10.1186/1471-2121-10-38

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