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Article

Differential roles of gangliosides in malignant properties of melanomas

21 Nov 2018

Abstract excerpt

Ganglioside GD3 is widely expressed in human malignant melanomas, and has been reported to be involved in the increased cell proliferation and invasion. In this study, we established GM3-, GM2-, GM1-, GD3-, or GD2-expressing melanoma cell lines by transfecting cDNAs of glyscosyltransferases, and effects of individual gangliosides on the cell phenotypes and signals were examined. The phenotypes of established...

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PMID: 30462668
DOI: 10.1371/journal.pone.0206881

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