Article
The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.
The Journal of biological chemistry - 13 Jul 2007
Shi Xiaohua, Ma Yan-Qing, Tu Yizeng, Chen Ka, Wu Shan, Fukuda Koichi, Qin Jun, Plow Edward F, Wu Chuanyue
Abstract excerpt
Integrin-mediated cell-matrix adhesion plays an important role in control of cell behavior. We report here that MIG-2, a widely expressed focal adhesion protein, interacts with beta1 and beta3 integrin cytoplasmic domains. Integrin binding is mediated by a single site within the MIG-2 FERM domain...
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