Article
TCR gene polymorphisms and autoimmune disease.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Apr 1996
Kay R A
Abstract excerpt
Autoimmunity may result from abnormal regulation within the immune system. As the T cell is the principal regulator of the immune system and its normal function depends on immune recognition or self/non-self discrimination, abnormalities of the idiotypic T-cell receptor (TCR) may be one cause of autoimmune disease. The TCR is a clonally distributed, cell-surface heterodimer which binds peptide antigen when...
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