Article
CTLA-4 and the genetic predisposition to autoimmunity.
Bratislavske lekarske listy - 1 Jan 2005
Dallos T, Kovacs L
Abstract excerpt
Due to the wide spectrum of clinical manifestations and their epidemiological dimensions, autoimmune diseases represent an important medical issue. They are the consequence of the loss of immune tolerance to autoantigens, which in turn is a result of the interaction of environmental, as well as genetic factors. The predisposing role of HLA antigens is widely accepted; nonetheless, it does not fully explain the...
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