Article
[Predictive value of intracellular accumulation of daunorubicin and P-glycoprotein expression simultaneously determined by flow cytometry in adult acute myeloid leukemias].
Annales de biologie clinique - 1 Jan 1996
Guerci A, Merlin J L, Missoum N, Feldmann L, Marchal S, Guerci O
Abstract excerpt
Multidrug resistance (MDR) phenotype expression was evaluated retrospectively in 87 patients with acute myeloid leukemia (AML), 69 with de novo AML, ten with relapsed AML and eight with AML secondary to myelodysplastic syndrome (MDS). MDR phenotype, characterized by P-glycoprotein expression (MRK...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Adult
- Bone Marrow
- Daunorubicin
- Drug Resistance, Multiple
- Flow Cytometry
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Myeloid
- Multivariate Analysis
- Phenotype
- Prospective Studies