Article
Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Cytometry - 1 Sept 1994
Maslak P, Hegewisch-Becker S, Godfrey L, Andreeff M
Abstract excerpt
Expression of the multidrug-resistant (MDR) phenotype was investigated in acute leukemia using a monoclonal antibody (HYB-241) directed against a cell surface epitope of the 180 kd P-glycoprotein (gp180) by flow cytometric analysis of clinical samples. Samples from sixty-four patients were tested...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Adolescent
- Adult
- Aged
- Antibiotics, Antineoplastic
- Antineoplastic Combined Chemotherapy Protocols
- Biological Transport
- Blast Crisis
- Child
- Child, Preschool
- Daunorubicin
- Drug Resistance, Multiple
- Female
- Flow Cytometry
- Humans
- Leukemia
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive