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Article

Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia.

Cancer chemotherapy and pharmacology - 1 Nov 2016

Varatharajan Savitha, Panetta John C, Abraham Ajay, Karathedath Sreeja, Mohanan Ezhilpavai, Lakshmi Kavitha M, Arthur Nancy, Srivastava Vivi M, Nemani Sandeep, George Biju, Srivastava Alok, Mathews Vikram, Balasubramanian Poonkuzhali

Abstract excerpt

PURPOSE: Chemotherapy drug resistance and relapse of the disease have been the major factors limiting the success of acute myeloid leukemia (AML) therapy. Several factors, including the pharmacokinetics (PK) of Cytarabine (Ara-C) and Daunorubicin (Dnr), could contribute to difference in treatment outcome in AML. METHODS: In the present study, we evaluated the plasma PK of Dnr, the influence of genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27738808
DOI: 10.1007/s00280-016-3166-8
PMCID: PMC7115946

Genes

CBR1
ABCB1
ABCG2
CBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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