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Article

Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

Genetics - 1 May 1996

Noble S M, Guthrie C

Abstract excerpt

Genetic approaches in Saccharomyces cerevisiae have identified 38 genes required for efficient RNA splicing. The majority have been found by screening (high) temperature-sensitive (ts) mutants for those defective in splicing, an approach limited by the presence of ts hotspots and by the fact that many essential genes rarely mutate to the ts phenotype. To identify novel genes, we screened a collection of 340...

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PMID: 8722763
DOI: 10.1093/genetics/143.1.67
PMCID: PMC1207296

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