Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

doi:10.1093/genetics/143.1.67

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Article

Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

Genetics - 1 May 1996

Noble S M, Guthrie C

Abstract excerpt

Genetic approaches in Saccharomyces cerevisiae have identified 38 genes required for efficient RNA splicing. The majority have been found by screening (high) temperature-sensitive (ts) mutants for those defective in splicing, an approach limited by the presence of ts hotspots and by the fact that...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Cold Temperature
Conserved Sequence
DNA Primers
Exons
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Genotype
Humans
Molecular Sequence Data
Mutagenesis
Oligodeoxyribonucleotides
Phenotype
RNA Helicases

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