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Article

Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1.

Nucleic acids research - 15 Nov 2002

Revers L F, Cardone J M, Bonatto D, Saffi J, Grey M, Feldmann H, Brendel M, Henriques J A P

Abstract excerpt

The conditionally-lethal pso4-1 mutant allele of the spliceosomal-associated PRP19 gene allowed us to study this gene's influence on pre-mRNA processing, DNA repair and sporulation. Phenotypes related to intron-containing genes were correlated to temperature. Splicing reporter systems and RT-PCR showed splicing efficiency in pso4-1 to be inversely correlated to growth temperature. A single amino acid...

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Source

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Identifiers

PMID: 12434004
DOI: 10.1093/nar/gkf632
PMCID: PMC137178

Genes

DBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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