Article
Genetic mechanisms in esophageal carcinogenesis: frequent deletion of 3p and 17p in premalignant lesions.
Genes, chromosomes & cancer - 1 Mar 1996
Shimada M, Yanagisawa A, Kato Y, Inoue M, Shiozaki H, Monden M, Nakamura Y
Abstract excerpt
Although dysplasia of the esophagus is thought to be the precursor lesion of esophageal squamous cell carcinoma (ESC), the sequence of genetic events during esophageal carcinogenesis is unclear. Using the polymerase chain reaction, we examined allelic losses at microsatellite loci in DNAs isolate...
Topics
- Alleles
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 9
- DNA, Satellite
- Esophageal Neoplasms
- Esophagus
- Humans
- Hyperplasia
- Neoplasm Invasiveness
- Polymerase Chain Reaction
- Precancerous Conditions