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Article

Genetic mechanisms in esophageal carcinogenesis: frequent deletion of 3p and 17p in premalignant lesions.

Genes, chromosomes & cancer - 1 Mar 1996

Shimada M, Yanagisawa A, Kato Y, Inoue M, Shiozaki H, Monden M, Nakamura Y

Abstract excerpt

Although dysplasia of the esophagus is thought to be the precursor lesion of esophageal squamous cell carcinoma (ESC), the sequence of genetic events during esophageal carcinogenesis is unclear. Using the polymerase chain reaction, we examined allelic losses at microsatellite loci in DNAs isolated from 106 lesions among 32 patients with ESC. Allelic losses on 3p or 17p occurred frequently even in dysplastic...

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PMID: 8721680
DOI: 10.1002/(SICI)1098-2264(199603)15:3<165::AID-GCC3>3.0.CO;2-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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