Article
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.
The Journal of cell biology - 16 Jul 2007
Sun Yue, Ling Kun, Wagoner Matthew P, Anderson Richard A
Abstract excerpt
Phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) modulates a plethora of cytoskeletal interactions that control the dynamics of actin assembly and, ultimately, cell migration. We show that the type Igamma phosphatidylinositol phosphate kinase 661 (PIPKIgamma661), an enzyme that generates PI4,5P(2), is required for growth factor but not G protein-coupled receptor-stimulated directional migration. By generating...
Topics
- Cell Line, Tumor
- Cell Movement
- Epidermal Growth Factor
- HeLa Cells
- Humans
- Hydrolysis
- Models, Biological
- Mutation
- Phosphatidylinositol 4,5-Diphosphate
- Phospholipase C gamma
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor)
- Recombinant Proteins
- Talin