Article
Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.
The Journal of cell biology - 1 Aug 1996
Kasper D, Dittmer F, von Figura K, Pohlmann R
Abstract excerpt
Mouse embryonic fibroblasts that are deficient in the two mannose 6-phosphate receptors (MPRs) MPR 46 and MPR 300 missort the majority (> or = 85%) of soluble lysosomal proteins into the medium. Human MPR 46 and MPR 300 were expressed in these cells to test whether overexpression of a single type...
Topics
- Animals
- Antigens, CD
- Biological Transport
- Cathepsin D
- Cell Line, Transformed
- Fibroblasts
- Glycoside Hydrolases
- Humans
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Mice
- Mutation
- Proteins
- Receptor, IGF Type 2
- Recombinant Proteins
- Transfection