Article
The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
The FEBS journal - 1 Feb 2008
Fujita Naonobu, Tamura Ayako, Higashidani Aya, Tonozuka Takashi, Freeze Hudson H, Nishikawa Atsushi
Abstract excerpt
Mannose for mammalian glycan biosynthesis can be imported directly from the medium, derived from glucose or salvaged from endogenous or external glycans. All pathways must generate mannose 6-phosphate, the activated form of mannose. Imported or salvaged mannose is directly phosphorylated by hexokinase, whereas fructose 6-phosphate from glucose is converted to mannose 6-phosphate by phosphomannose isomerase (PMI)....
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