Article
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.
The Journal of biological chemistry - 15 Feb 2002
Mathews Paul M, Guerra Carolyn B, Jiang Ying, Grbovic Olivera M, Kao Benjamin H, Schmidt Stephen D, Dinakar Ravi, Mercken Marc, Hille-Rehfeld Annette, Rohrer Jack, Mehta Pankaj, Cataldo Anne M, Nixon Ralph A
Abstract excerpt
Prominent endosomal and lysosomal changes are an invariant feature of neurons in sporadic Alzheimer's disease (AD). These changes include increased levels of lysosomal hydrolases in early endosomes and increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partially localized to early endosomes. To determine whether AD-associated redistribution of lysosomal hydrolases...
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