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Article

Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants.

The Biochemical journal - 15 Jul 2004

Hansen Gaute, Berg Thomas, Riise Stensland Hilde M F, Heikinheimo Pirkko, Klenow Helle, Evjen Gry, Nilssen Øivind, Tollersrud Ole K

Abstract excerpt

Human LAMAN (lysosomal a-mannosidase) was synthesized as a 120 kDa precursor in transfected COS cells [African-green-monkey kidney cells], which was partly secreted as a single-chain form and partly sorted to the lysosomes being subsequently cleaved into three peptides of 70, 40 and 15 kDa respectively. Both the secreted and the lysosomal forms contained endo H (endoglucosidase H)-resistant glycans, suggesting a...

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Identifiers

PMID: 15035660
DOI: 10.1042/BJ20031499
PMCID: PMC1133862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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