I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors.

doi:10.1023/a:1008823315416

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Article

I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors.

Transgenic research - 1 Nov 1998

Dittmer F, Hafner A, Ulbrich E J, Moritz J D, Schmidt P, Schmahl W, Pohlmann R, Figura K V

Abstract excerpt

Mannose 6-phosphate receptor deficient mice were generated by crossing mice carrying null alleles for Igf2 and the 300 kDa and 46 kDa mannose 6-phosphate receptors, Mpr300 and Mpr46. Pre- and perinatal lethality of mice nullizygous for Igf2, Mpr300 and Mpr46 was increased. Triple deficient mice surviving the first postnatal day had normal viability and developed a phenotype resembling human I-cell disease. The...

Topics

Animals
Blotting, Western
Bone and Bones
Female
Genomic Imprinting
Genotype
Heterozygote
Lysosomes
Male
Mice
Mucolipidoses
Phenotype
Radiography
Receptor, IGF Type 2

Source

Open in PubMed

Identifiers

PMID: 10341453
DOI: 10.1023/a:1008823315416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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