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Article

Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels.

Immunology and cell biology - 1 Sept 2014

Jackson Katherine J L, Wang Yan, Collins Andrew M

Abstract excerpt

Somatic point mutations provide glimpses into B-cell histories, and mutation numbers generally correlate with antibody affinity. We recently proposed a model of human isotype function, based in part on mutation analysis, in which the dominant pathway of isotype switching involves B cells moving s...

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Share to Complementarity Determining Regions
Share to Gene Rearrangement, B-Lymphocyte
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24913324
DOI: 10.1038/icb.2014.44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24913324-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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