Article
Self-reactive VH4-34-expressing IgG B cells recognize commensal bacteria.
The Journal of experimental medicine - 3 Jul 2017
Schickel Jean-Nicolas, Glauzy Salomé, Ng Yen-Shing, Chamberlain Nicolas, Massad Christopher, Isnardi Isabelle, Katz Nathan, Uzel Gulbu, Holland Steven M, Picard Capucine, Puel Anne, Casanova Jean-Laurent, Meffre Eric
Abstract excerpt
The germline immunoglobulin (Ig) variable heavy chain 4-34 (VH4-34) gene segment encodes in humans intrinsically self-reactive antibodies that recognize I/i carbohydrates expressed by erythrocytes with a specific motif in their framework region 1 (FWR1). VH4-34-expressing clones are common in the naive B cell repertoire but are rarely found in IgG memory B cells from healthy individuals. In contrast, CD27+IgG+ B...
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