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Article

Characteristics of IgVH genes used by human intestinal plasma cells from childhood.

Immunology - 1 Aug 1999

Boursier L, Dunn-Walters D K, Spencer J

Abstract excerpt

Plasma cells secreting immunoglobulin M (IgM) and IgA in human intestinal mucosa are the largest antibody-producing population in the human body. Despite this there have been relatively few studies of the characteristics and maturation of the genes which encode the mucosal immunoglobulins. We have previously demonstrated that intestinal plasma cells use highly mutated IgVH genes, likely to reflect germinal centre...

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Mucosal

Share to Immunoglobulin Class Switching

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Source

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Identifiers

PMID: 10457207
DOI: 10.1046/j.1365-2567.1999.00843.x
PMCID: PMC2326878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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