Article
IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies.
Immunological investigations - 1 Jan 2015
Bhat Neelima M, Kshirsagar Mihir A, Bieber Marcia M, Teng Nelson N H
Abstract excerpt
VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response in humans is dominated by the IgG2 subclass, here we tested whether VH4-34 encoded IgG showed...
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