Article
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999
Wright J H, Munar E, Jameson D R, Andreassen P R, Margolis R L, Seger R, Krebs E G
Abstract excerpt
The mitogen-activated protein kinase (MAPK) cascade is required for mitogenesis in somatic mammalian cells and is activated by a wide variety of oncogenic stimuli. Specific roles for this signaling module in growth were dissected by inhibiting MAPK kinase 1 (MAPKK1) activity in highly synchronized NIH 3T3 cells. In addition to the known role of this kinase in cell-cycle entry from G(0), the level of MAPKK...
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