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Article

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.

Molecular and cellular biology - 1 Feb 1991

L'Allemain G, Sturgill T W, Weber M J

Abstract excerpt

Mitogen-activated protein (MAP) kinase is a serine/threonine-specific protein kinase which is activated in response to various mitogenic agonists (e.g., epidermal growth factor, insulin, and the tumor promoter tetradecanoyl phorbol acetate [TPA]) and requires both threonine and tyrosine phosphorylation for activity. This enzyme has recently been shown to be identical or closely related to pp42, a protein which...

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Identifiers

PMID: 1990261
DOI: 10.1128/mcb.11.2.1002-1008.1991
PMCID: PMC359767

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Source receipt: pubmed, retrieved 7 Sept 2026.

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