Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.

Molecular and cellular biology - 1 Feb 1991

L'Allemain G, Sturgill T W, Weber M J

Abstract excerpt

Mitogen-activated protein (MAP) kinase is a serine/threonine-specific protein kinase which is activated in response to various mitogenic agonists (e.g., epidermal growth factor, insulin, and the tumor promoter tetradecanoyl phorbol acetate [TPA]) and requires both threonine and tyrosine phosphorylation for activity. This enzyme has recently been shown to be identical or closely related to pp42, a protein which...

Topics

Animals
Cell Line
Epidermal Growth Factor
Genetic Variation
Immunoblotting
Insulin
Kinetics
Mice
Phosphorylation
Protein Kinases
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 1990261
DOI: 10.1128/mcb.11.2.1002-1008.1991
PMCID: PMC359767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1990261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.PMID 1990261Read ↗

Complex mitogenic requirements of Na(+)-K(+)-Cl(-)-cotransport-deficient BALB/c-3T3 cells.Semantic proximity Read ↗

Induction of membrane ruffling by growth factors in morphologically TPA-resistant Balb/c3T3 TR4 cells.Semantic proximity Read ↗

Expression of platelet-derived growth factor-independent phenotypes in BALB/c 3T3 cell variant with high susceptibility to chemically or physically induced neoplastic cell transformation: dissociation from activation of protein kinase C.Semantic proximity Read ↗

Transformation is associated with an increase in sensitivity to TNF-mediated lysis as a result of an increase in TNF-induced protein tyrosine phosphatase activity.Semantic proximity Read ↗

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts.Semantic proximity Read ↗

A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.Semantic proximity Read ↗

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.Semantic proximity Read ↗

Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.Semantic proximity Read ↗

Severely decreased MARCKS expression correlates with ras reversion but not with mitogenic responsiveness.Semantic proximity Read ↗

Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.Semantic proximity Read ↗

Polyoma virus middle tumor antigen stimulates membrane-associated protein kinase C at lower levels than required for phosphatidylinositol kinase activation and neoplastic transformation.Semantic proximity Read ↗

Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.