Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor.

The Journal of biological chemistry - 2 Aug 1996

Jensen J, Serup P, Karlsen C, Nielsen T F, Madsen O D

Abstract excerpt

Development of a high capacity multiplex reverse transcriptase-polymerase chain reaction protocol has allowed us to screen lineage related rat islet tumors classified as alpha-, beta-, and delta-like as judged by their hormone profile for differential expression of more than 50 selected genes. We find that in addition to insulin the insulinoma express the normal beta-cell markers Pdx-1, IAPP, and Glut-2, and that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Molecular Sequence Data

Share to Phenotype

Share to Polymerase Chain Reaction

Share to RNA, Messenger

Source

Identifiers

PMID: 8702531
DOI: 10.1074/jbc.271.31.18749

Genes

GIP
IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor.PMID 8702531Read ↗

NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic β-Cell Development, Identity, and ProliferationSemantic proximity Read ↗

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read ↗

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferationSemantic proximity Read ↗

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta CellsSemantic proximity Read ↗

Transcription factors contributing to the pancreatic beta-cell phenotype.Semantic proximity Read ↗

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells ReprogrammingSemantic proximity Read ↗

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.Semantic proximity Read ↗

Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes.Semantic proximity Read ↗

Opposing actions of Arx and Pax4 in endocrine pancreas development.Semantic proximity Read ↗

Islet Cell and Extrapancreatic Expression of the LIM Domain Homeobox Geneisl-1Semantic proximity Read ↗

Generation of a novel Nkx6-1 Venus fusion reporter mouse lineSemantic proximity Read ↗

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.