Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing actions of Arx and Pax4 in endocrine pancreas development.

Genes & development - 15 Oct 2003

Collombat Patrick, Mansouri Ahmed, Hecksher-Sorensen Jacob, Serup Palle, Krull Jens, Gradwohl Gerard, Gruss Peter

Abstract excerpt

Genes encoding homeodomain-containing proteins potentially involved in endocrine pancreas development were isolated by combined in silico and nested-PCR approaches. One such transcription factor, Arx, exhibits Ngn3-dependent expression throughout endocrine pancreas development in alpha, beta-precursor, and delta cells. We have used gene targeting in mouse embryonic stem cells to generate Arx loss-of-function...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Genes, Lethal
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoglycemia

Share to Paired Box Transcription Factors

Share to Pancreas

Share to Transcription Factors

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 14561778
DOI: 10.1101/gad.269003
PMCID: PMC218152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing actions of Arx and Pax4 in endocrine pancreas development.PMID 14561778Read ↗

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.Semantic proximity Read ↗

Present status and expectation of aristaless-related homeobox (ARX) in endocrine pancreas.Semantic proximity Read ↗

Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expressionSemantic proximity Read ↗

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read ↗

ARX: a gene for all seasons.Semantic proximity Read ↗

The Role of ARX in Human Pancreatic Endocrine SpecificationSemantic proximity Read ↗

Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.Semantic proximity Read ↗

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expressionSemantic proximity Read ↗

Arx is required for normal enteroendocrine cell development in mice and humansSemantic proximity Read ↗

Arx homeobox gene is essential for development of mouse olfactory system.Semantic proximity Read ↗

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.Semantic proximity Read ↗

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.