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Article

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming

25 Nov 2010

Abstract excerpt

Reprogramming adult mammalian cells is an attractive approach for generating cell-based therapies for degenerative diseases, such as diabetes. Adult human liver cells exhibit a high level of developmental plasticity and have been suggested as a potential source of pancreatic progenitor tissue. An instructive role for dominant pancreatic transcription factors in altering the hepatic developmental fate along the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21108535
DOI: 10.1089/cell.2010.0030

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