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Article

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

1 Sept 2013

Abstract excerpt

Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell failure in diabetes. However, the molecular mechanisms that underlie the loss of beta cell features remain unclear. Here, we identify an Nkx6.1-controlled gene regulatory network as essential for maintaining the functional and molecular traits of mature beta cells. Conditional Nkx6.1 inactivation in adult mice caused...

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PMID: 24035389
DOI: 10.1016/j.celrep.2013.08.010

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