Article

Generation of a novel Nkx6-1 Venus fusion reporter mouse line

2021-01-29

Abstract excerpt

Nkx6-1 is a member of the Nkx family of homeodomain transcription factors (TF) that regulates motor neuron development, neuron specification and pancreatic endocrine and β-cell differentiation. To facilitate the isolation and tracking of Nkx6-1-expressing cells, we have generated a novel Nkx6-1 Venus Fusion (Nkx6-1-VF) reporter allele. The Nkx6-1-VF knock-in reporter is regulated by endogenous cis-regulatory eleme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edd8aed2-7e2d-5aa0-a937-6ac71ea071b3
DOI: 10.1101/2021.01.29.428800

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of a novel Nkx6-1 Venus fusion reporter mouse lineDOI 10.1101/2021.01.29.428800Read

Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line.Semantic proximity Read

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferationSemantic proximity Read

NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic β-Cell Development, Identity, and ProliferationSemantic proximity Read

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populationsSemantic proximity Read

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta CellsSemantic proximity Read

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.Semantic proximity Read

The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression.Semantic proximity Read

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.Semantic proximity Read

Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitorsSemantic proximity Read

Distinct Gene Expression Programs Function in Progenitor and Mature Islet CellsSemantic proximity Read

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.Semantic proximity Read