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Article

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.

Development (Cambridge, England) - 1 Jul 2005

Henseleit Korinna D, Nelson Shelley B, Kuhlbrodt Kirsten, Hennings J Christopher, Ericson Johan, Sander Maike

Abstract excerpt

In diabetic individuals, the imbalance in glucose homeostasis is caused by loss or dysfunction of insulin-secreting beta-cells of the pancreatic islets. As successful generation of insulin-producing cells in vitro could constitute a cure for diabetes, recent studies have explored the molecular pr...

Read the complete abstract on PubMed

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to Islets of Langerhans

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Source

Identifiers

PMID: 15944193
DOI: 10.1242/dev.01875

Genes

MYT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15944193-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.PMID 15944193Read ↗

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta CellsSemantic proximity Read ↗

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read ↗

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.Semantic proximity Read ↗

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferationSemantic proximity Read ↗

NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic β-Cell Development, Identity, and ProliferationSemantic proximity Read ↗

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.Semantic proximity Read ↗

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.Semantic proximity Read ↗

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.Semantic proximity Read ↗

Generation of a novel Nkx6-1 Venus fusion reporter mouse lineSemantic proximity Read ↗

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.Semantic proximity Read ↗

Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line.Semantic proximity Read ↗

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.Semantic proximity Read ↗

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