Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation

29 Oct 2020

Abstract excerpt

Abstract Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-producing β cell mass. Pluripotent stem cells (PSCs) can potentially offer an unlimited supply of functional β cells for cellular therapy and disease modeling of DM....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33121533
DOI: 10.1186/s13287-020-01977-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferationPMID 33121533Read ↗

NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic β-Cell Development, Identity, and ProliferationSemantic proximity Read ↗

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta CellsSemantic proximity Read ↗

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read ↗

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells ReprogrammingSemantic proximity Read ↗

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.Semantic proximity Read ↗

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitorsSemantic proximity Read ↗

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.Semantic proximity Read ↗

Generation of a novel Nkx6-1 Venus fusion reporter mouse lineSemantic proximity Read ↗

Novel MAFA+, ISL1+, NKX6-1-stem cell derived pancreatic cell clusters secrete insulin and control blood glucose in rodent models of diabetesSemantic proximity Read ↗

Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitorsSemantic proximity Read ↗

Transcription factors contributing to the pancreatic beta-cell phenotype.Semantic proximity Read ↗

PDX1 is the cornerstone of pancreatic β-cell functions and identitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.