Article
Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice.
Oncogene - 20 Jun 1996
Hardin J D, Boast S, Mendelsohn M, de los Santos K, Goff S P
Abstract excerpt
Mice carrying homozygous mutations in the c-abl gene (abl-(m1) or abl2) exhibit severe, though variable phenotypes, including a high rate of postnatal mortality, runting, morphological abnormalities, a susceptibility to infections, and selected immune system defects. To further determine the role...
Topics
- Animals
- Base Sequence
- Genes, Lethal
- Genetic Complementation Test
- Genetic Predisposition to Disease
- Homozygote
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Pedigree
- Phenotype
- Proto-Oncogene Proteins c-abl