Article
Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice.
Oncogene - 20 Jun 1996
Hardin J D, Boast S, Mendelsohn M, de los Santos K, Goff S P
Abstract excerpt
Mice carrying homozygous mutations in the c-abl gene (abl-(m1) or abl2) exhibit severe, though variable phenotypes, including a high rate of postnatal mortality, runting, morphological abnormalities, a susceptibility to infections, and selected immune system defects. To further determine the role of the c-Abl protein in vivo, we have generated three lines of mice expressing c-abl transgenes. These minigenes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.