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Article

Expression of a <i>CALM-AF10</i> Fusion Gene Leads to <i>Hoxa</i> Cluster Overexpression and Acute Leukemia in Transgenic Mice

1 Sept 2007

Abstract excerpt

To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo, we generated transgenic mice that expressed a CALM-AF10 fusion gene. Depending on the transgenic line, at least 40% to 50% of the F(1) generation mice developed acute leukemia at a median age of 12 months. Leukemic mice typically had enlarged spleens, invasion of parenchymal organs with malignant cells, and tumors with myeloid...

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PMID: 17804713
DOI: 10.1158/0008-5472.can-06-3749

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Related research

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Expression of a <i>CALM-AF10</i> Fusion Gene Leads to <i>Hoxa</i> Cluster Overexpression and Acute Leukemia in Transgenic MicePMID 17804713Read ↗

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Semantic proximity Read ↗

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Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patientsSemantic proximity Read ↗

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Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.Semantic proximity Read ↗

Consistent detection of <i>CALM‐AF10</i> chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcriptsSemantic proximity Read ↗

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AMLSemantic proximity Read ↗

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.Semantic proximity Read ↗

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.Semantic proximity Read ↗

The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.Semantic proximity Read ↗

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.Semantic proximity Read ↗

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10Semantic proximity Read ↗

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