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Article

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

International immunology - 1 Mar 2007

Lam Queenie Lai Kwan, Lo Cherry Kam Chun, Zheng Bo-Jian, Ko King-Hung, Osmond Dennis G, Wu Gillian E, Rottapel Robert, Lu Liwei

Abstract excerpt

Previous studies on c-Abl-deficient mice have shown high post-natal mortality and lymphopenia. However, the mechanisms by which c-Abl may influence B lymphopoiesis remain obscure. In this study, we analyzed B cell sub-populations at various differentiation stages in the bone marrow (BM) of c-Abl-deficient mice. Phenotypic analyses revealed that c-Abl(-/-) pro-B cells were reduced to half of normal incidence and...

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Source

Identifiers

PMID: 17229817
DOI: 10.1093/intimm/dxl143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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