Article
Posttranslational regulation of p53 tumor suppressor protein function.
Critical reviews in oncogenesis - 1 Jan 1994
Maxwell S A, Roth J A
Abstract excerpt
Alteration of the p53 gene by deletion and mutation is the most common denominator yet identified among human cancers (Hollstein et al., 1991; Caron de Fromental and Soussi, 1992). The involvement of the p53 gene in such a broad scope of human cancers warrants further investigation into its mechanism of action in regulating cell growth. The wild-type p53 protein restricts cell growth in the G1 phase of the cell...
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