Article
Posttranslational regulation of p53 tumor suppressor protein function.
Critical reviews in oncogenesis - 1 Jan 1994
Maxwell S A, Roth J A
Abstract excerpt
Alteration of the p53 gene by deletion and mutation is the most common denominator yet identified among human cancers (Hollstein et al., 1991; Caron de Fromental and Soussi, 1992). The involvement of the p53 gene in such a broad scope of human cancers warrants further investigation into its mecha...
Topics
- Allosteric Regulation
- Animals
- Cell Cycle
- DNA Replication
- Humans
- Mutation
- Organ Specificity
- Oxidation-Reduction
- Phosphorylation
- Protein Conformation
- Protein Processing, Post-Translational
- Tumor Suppressor Protein p53