An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death

Abstract excerpt

Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animal Disease Management and Epidemiology
• Share to Vector-Borne Animal Diseases
• Share to Viral gastroenteritis research and epidemiology