Article
Frequent p53 mutation in mouse tumors induced by repeated beta-irradiation.
Molecular carcinogenesis - 1 Dec 1994
Ootsuyama A, Makino H, Nagao M, Ochiai A, Yamauchi Y, Tanooka H
Abstract excerpt
On examination of cDNA of the p53 gene in 65 murine tumors of the skin and bone produced by repeated exposure to a suprathreshold dose of 1-8 Gy of 90Sr-90Y beta-radiation per exposure, we found 20 cases of mutation: 11 minute deletions (loss of 1-24 bp), including two cases possibly due to aberr...
Topics
- Animals
- Base Sequence
- Beta Particles
- Bone Neoplasms
- DNA Transposable Elements
- DNA, Neoplasm
- Female
- Gene Deletion
- Genes, p53
- Mice
- Mice, Inbred ICR
- Molecular Sequence Data
- Mutation
- Neoplasms, Radiation-Induced
- Repetitive Sequences, Nucleic Acid
- Skin Neoplasms
- Tumor Suppressor Protein p53