A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development.

doi:10.1006/geno.1993.1292

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Article

A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development.

Genomics - 1 Jul 1993

Gibbs M, Collick A, Kelly R G, Jeffreys A J

Abstract excerpt

The highly variable mouse minisatellite Hm-2 is located on chromosome 9 and consists of GGCA tetranucleotide repeats with alleles containing up to 5000 repeat units. This locus is unstable with a germline mutation rate to new length alleles of at least 3.6% per gamete. Hm-2 also shows substantial somatic instability, producing mutational mosaicism detectable in 20% of adult mice. Analysis of allele dosage in mice...

Topics

Alleles
Animals
Base Sequence
Blastocyst
Chromosome Mapping
DNA, Satellite
Embryonic and Fetal Development
Mice
Mice, Inbred Strains
Molecular Sequence Data
Mosaicism
Mutation
Organ Specificity
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8406443
DOI: 10.1006/geno.1993.1292

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