Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations.

doi:10.1016/s0165-1218(96)90069-5

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Article

Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations.

Mutation research - 5 Jul 1996

Andreassen A, Kure E H, Nielsen P S, Autrup H, Haugen A

Abstract excerpt

Polycyclic aromatic hydrocarbon (PAH)-DNA adducts were studied in human lung from 39 lung cancer patients by synchronous fluorescence spectrophotometric (SFS) and 32P-postlabeling assays. Regression analysis of the samples failed to detect any correlation between benzo[a]pyrene-diolepoxide (BPDE)...

Topics

Adult
Aged
DNA Adducts
Female
Genes, p53
Humans
Lung
Male
Middle Aged
Mutation
Polycyclic Aromatic Hydrocarbons
Spectrometry, Fluorescence

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