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Article

Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes.

Cancer research - 1 Aug 1993

Shields P G, Bowman E D, Harrington A M, Doan V T, Weston A

Abstract excerpt

Molecular dosimetry for polycyclic aromatic hydrocarbon-DNA adducts, genetic predisposition to cancer, and their interrelationships are under study in numerous laboratories. This report describes a modified 32P-postlabeling assay for the detection of polycyclic aromatic hydrocarbon-DNA adducts that uses immunoaffinity chromatography to enhance chemical specificity and quantitative reliability. The assay...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Base Sequence
Cytochrome P-450 Enzyme System
DNA
DNA Adducts
Deoxyguanosine
Disease Susceptibility
Genotype
Glutathione Transferase
Humans
Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polycyclic Compounds

Polymorphism, Genetic

Source

Identifiers

PMID: 8339251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8339251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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