Article
Analysis of DNA adducts in smokers' lung and urothelium by 32P-postlabelling: metabolic phenotype dependence and comparisons with other exposure markers.
IARC scientific publications - 1 Jan 1993
Bartsch H, Castegnaro M, Camus A M, Schouft A, Geneste O, Rojas M, Alexandrov K
Abstract excerpt
Carcinogen-DNA adduct levels in lung parenchyma (surgical specimens) and urothelial (exfoliated) cells of smokers, ex-smokers and non-smokers were investigated. DNA adducts were analysed by 32P-postlabelling and levels were compared with tissue-specific activity of cytochrome P450-related enzymes...
Topics
- Aryl Hydrocarbon Hydroxylases
- Biomarkers
- Carcinogens
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 Enzyme System
- DNA
- DNA Damage
- Humans
- Lung
- Lung Neoplasms
- Oxidoreductases
- Phenotype
- Phosphorus Radioisotopes
- Smoking
- Urinary Bladder